KMID : 1044720170070010035
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Journal of Lifestyle Medicine 2017 Volume.7 No. 1 p.35 ~ p.40
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Effects of Combined Rocuronium and Cisatracurium in Laparoscopic Cholecystectomy
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Park Woo-Young
Lee Kwang-Ho Lee Young-Bok Kim Myeong-Hoon Lim Hyun-Kyo Choi Jong-Bum
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Abstract
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Background: Laparoscopic upper abdominal surgery can cause spontaneous respiration due to diaphragmatic stimulation and intra-abdominal CO2 inflation. Therefore, sufficient muscle relaxation is necessary for a safe surgical environment.
Methods: We investigated if the combination of rocuronium and cisatracurium can counteract the delayed onset of cisatracurium¡¯s action and delayed recovery of muscle relaxation and whether the dosage of rocuronium, which is metabolized hepatically, can be reduced. A total of 75 patients scheduled for laparoscopic cholecystectomy with an American Society of Anesthesiology physical status I-II, in the age range of 20?60 years, and with a 20?30 kg/m2 body mass index were included in the study.
Results: The patients were divided into the following groups: combination group (Group RC, rocuronium 0.3 mg/kg and cisatracurium 0.05 mg/kg), rocuronium group (Group R, rocuronium 0.6 mg/kg), and cisatracurium group (Group C, cisatracurium 0.1 mg/kg), and the onset, 25% duration, recovery index, and addition/time ratio were measured. Patients in Group RC exhibited a significantly different addition/time ratio compared with patients in the other two groups (p = 0.003).
Conclusion: During laparoscopic cholecystectomy, the 95% effective dose of rocuronium in combination with cisatracurium is expected to provide a sufficient muscle relaxant effect.
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KEYWORD
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Cholecystectomy, Cisatracurium, Laparoscopy, Rocuronium
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